This unique biology makes it highly specific,” said Taylor.Ī limitation of the study is that the results don’t provide key pieces of information, such as the location of the cancerous tissues in the body. Pervasive expression of ORF1p in carcinomas and the lack of expression in normal tissues makes ORF1p unlike other protein biomarkers, which have normal expression levels. “Our results bolster the emerging idea that ORF1p expression is a ‘hallmark of cancer’ expressed starting early in the disease process. Studies in tissue samples from ~200 colon cancer and 75 esophageal biopsies, obtained from patients at different disease stages, showed that ORF1p tissue expression was prevalent in carcinomas and high-risk precursor lesions. The ultrasensitive assessment tool successfully quantified ORF1p in cancer patient blood samples, but only in very rare ‘healthy’ patients, supporting the specificity for cancer detection. Teaming up with investigators across Dana-Farber, Mass General Brigham, Beth Israel Deaconess, and MIT in Boston and from Rockefeller University, University of Pennsylvania, University of Washington (Seattle), Johns Hopkins, Groningen (Netherlands), and Canon Medical, the researchers tested blood samples from patients with different types of cancers, including ovarian and colorectal cancer. ![]() “It’s created more questions for us to explore and sparked interest among collaborators across many institutions.” “We were shocked by how well this test worked in detecting the biomarker’s expression across cancer types,” said co-first author Martin Taylor, MD, PhD, of the Department of Pathology at Massachusetts General Hospital, the other founding member of Mass General Brigham. The authors describe their first investigation of the test as a pilot experiment that wound up working better than they had imagined, which was followed by a series of engineering improvements and iterations in patient samples. Researchers have long sought a sensitive, accurate test to detect ORF1p. The test is designed to detect the open reading frame 1 protein (ORF1p), a transposable element protein that’s known to occur in many cancers but not in corresponding normal tissue, and that can indicate high risk of cancer lethality. The new study leverages a single-molecule-based detection technology known as SIMOA that was developed by the Walt lab. “Our results show that we can detect levels of this pan-cancer biomarker in the blood of patients with many types of cancers.” Walt is also a core faculty member at the Wyss Institute. “Cancer biomarker detection is a burgeoning area of research and is still a young field,” said co-senior author David Walt, PhD, of the Department of Pathology at Brigham and Women’s Hospital, a founding member of Mass General Brigham. "There's a lot of excitement as our work continues." ![]() "We were fortunate to assemble this tremendous team to push the limits of these assays and obtain and test these precious samples," said Burns, the Chair of the Department of Pathology. The tool showed promise for early cancer detection and disease monitoring, and could potentially be used in conjunction with other tools for detection, risk stratification, and treatment.ĭana-Farber's Kathleen Burns, MD, PhD, is co-senior author of the study published in Cancer Discovery. Each test can be performed with merely half a drop of blood (25 microliters). ![]() In a study led by investigators from Dana-Farber Cancer Institute, Mass General Brigham, and the Wyss Institute for Biologically Inspired Engineering at Harvard University in collaboration with researchers from across the country and beyond the U.S., researchers developed a low-cost, ultrasensitive blood test to detect minute levels of a cancer biomarker that is highly specific to multiple common cancers. But current cancer assessment methods have limited specificity and sensitivity and can be prohibitively expensive. Diagnostic tools for timely, accurate and inexpensive early cancer detection that can assess risk or monitor response to treatment could help patients get the care they need faster and improve existing care strategies.
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Information about the exams and fingerprinting may be found on PSI's website in the Candidate Information Bulletin (it's very important that you read it). Call 85 to schedule and pay for an exam or go to the PSI's website. The State insurance exams are administered by PSI. You may apply for your license once you have passed an exam (a score of 70% is passing) and meet all the qualifications under RCW 48.17.090.You may schedule to have your fingerprints taken at PSI.You may schedule an exam with PSI at any time, but Intellipass recommends 20 hours of self-study using our courseware.You will need to pass a separate exam for each line of insurance you require.You are required to pass a state exam in order to get an insurance license.Pre-licensing Requirements for the lines of Life, Disability, Property, Casualty, Personal lines. and 2:00 p.m., Pacific Time.Washington State Pre-licensing Requirements If you have examination scheduling questions, please call PSI at (833) 518-7456 to speak with a Consumer Service Representative Monday through Friday between 4:30 a.m. The Department's Examination Unit Phone Number: (916) 492-3570 and Email Address Examinations: Time Limit and Number of Questions.PSI's Remote Proctored Examination Technical Assistance Phone Number: (844) 267-1017.PSI's California Customer Service Phone Number: (833) 518-7456.For all PSI inquiries, including scheduling or rescheduling your examination, checking your scheduled examination time and date, and reviewing the examination admittance requirements visit PSI's Examination Scheduling Service.This fee is in addition to the Department's license examination fee. There is a $43 convenience fee to take the remote test. If you have any questions, please review the Department's Remote Proctored Licensing Examination Frequently Asked Questions. The Department will continue to partner with PSI to maintain the integrity and security of the examination process. The PSI Bridge TM platform provides secure and flexible remote proctoring services. The remote testing is proctored by PSI, through PSI’s Bridge TM technology. PSI also provides license applicants with the option to take a remote online proctored license examination (remote testing) for all insurance licensing examinations. Remote Online Proctored License Examinations Information about these additional locations is available on PSI's Examination Scheduling Service when individuals are in the process of scheduling their examination. All PSI locations have free parking and are available for Saturday examinations in addition to Monday through Friday. There is a $43 convenience fee to take an examination at the PSI locations. To complement the Department examination site in Los Angeles, PSI offers 20 additional sites statewide where individuals may take their qualifying license examination and obtain the required fingerprints. PSI provides additional examination sites and other test development services for the Department for individuals to have more choices on the location and times for taking their examinations. Individuals may schedule their examinations with PSI either online or by telephone at (833) 518-7456. ![]() ![]() Instructions for scheduling examinations are posted on PSI's Examination Scheduling Service. PSI Services LLC (PSI), a California-based company providing state-based regulatory licensure services, handles the scheduling of examinations for individuals licensed by the California Department of Insurance's (Department) Producer Licensing Bureau. ![]() The intakes are all cool air since inside doesn't get hot whatsoever. With how my tower is situated I didn't want the exhaust air (which will be hotter if the rads are my intake) blowing towards me. My GPU will be getting replaced within a month anyway so that will cue some other upgrades as well. I want 4 loops if possible inside the case, 3 at a minimum. Once I finalize the current design I'm going to start planning how my second system is going to run. ![]() ![]() Other than these things I've been happy with the case. front radiator thickness is limited to 60mm if you want a push/pull due to the drive bays 3.5" drive bay is non-removable, but I plan on modding my case and making a smaller enclosure there The pump mounting area is very small and forced me to stagger the two D5's Once I add my second system I'll flip the front ones to be my intake since I won't really have a choice at that point.Ĭorsair made some design compromises compared to other towers I've built. My temps dropped by an average Delta of 13☌ under heavy loads so there's no need to change it current. Pictures of the build will be added as I get the new parts in next week!Ĭlick to expand.With how my tower is situated I didn't want the exhaust air (which will be hotter if the rads are my intake) blowing towards me. EKWB full nickel/plexi block for the CPU and GPU Uplift Desk side take with Bamboo top (48"*30") Cable Mod custom PCIE x8, ATX, EPS, SATA power and Molex cablesĪs for the peripherals here's what my 'office' has: Samsung 960 EVO 500GB M.2 SSD (boot drive) Corsair Green PSU individually sleeved cables 10,000mm of Thermaltake V Tubular 16mm PTEG (You can never have too much tubing) Primochill 3/8-1/2 soft tubing (for the back plumbing) Alphacool Nexxos 480mm UT 60 radiator x2 Corsair Dominator Platinum DDR4 3000mhz 8GB RAM x4 OC to 3100mhz My primary will likely consist of Intel's next-gen X399 (not to be confused with AMD) and a GTX Titan T (whatever it will be called assuming one launches this year).įor now here's a rundown of what's going to get done and the parts being used: The plan is to run my i7 6800K and EVGA 1080FTW on a mini ITX board as the secondary system. I won't finish the complete project until Intel next gen of HEDT CPUs comes out, so, for now, I'll be keeping my current internal hardware with no secondary system. This time around I'm planning to implement a dual system with a minimum of 3 full loops. My previous build took place in an equally large Thermaltake The Tower 900 which has been great.įor those of you who didn't catch my last build, I'll link it here: I decided it was time for another super tower build since Corsair launched their massive Obsidian 1000D case. ![]() Now I just gotta work on building a find_package that can tolerate different dll’s depending on whether the configuration mode is Debug or Release… Sigh… CMake is not my favorite tool. Not pretty, but does solve the problem of the two separate pieces of code elegantly working together… ![]() If the length of the build directory and the target name are still too long to. To build, select the target simpleproject.exe on the top, and use the shortcut CTRL + SHIFT + B. Figure 2: Opening a CMake project with Visual Studio. 2. CMake produces Visual Studio solutions seamlessly. A library target name: The generated link line will have the full path to the linkable library file associated with the target. Firstly, simply click on Open a local folder and select the simpleprogram directory. Mentions, so instead I cobbled mine together from the objLoader Cinder sample: # For cmake_pathĬmake_minimum_required( VERSION 3.20 FATAL_ERROR )Ĭmake_path(SET CINDER_PATH "D:/SDKS/cinder_0.9.2_vc2015")Ĭmake_path(SET APP_PATH "$ -E copy_if_different # which executes "cmake - E copy_if_different." The name of the task in the project file is the same as the name of the task class. I couldn’t find the sample CMake file that this page: ![]() In which the author is experiencing the exact issue I’m currently seeing, except whether I use win32 or 圆4, I keep getting the same error. That said, I’m getting the following error trying to generate my project:ĬMake Error at dependencies/cinder/proj/cmake/modules/cinderMakeApp.cmake:65 (find_package):Ĭould not find a package configuration file … My day to day work flow is on Windows 10 however and I understand CMake support on windows is “experimental”. I’m pretty new to CMake but am really enjoying it so far. I’m moving my build system to CMake and I’m digging all the awesome support that has been added recently. Using cmake to generate cinder projects on windows Using Cinder A similar question was asked a few months ago, where I advised the use of target properties and also referred to another answer. ![]() ![]() STOP PRESS: What has become clear, to me at least, is that the compiling is a bit counter-intuitive to users of Microsoft Word – In Scrivener 3 for Windows you can basically write in any paragraph structure, font or size you want in your manuscript, then set your styles and formatting at the end. I’m confident, from past experience, there will be help out there when I get to that point. I’m afraid I can’t offer any solutions at present – I’m trying to write, rather than being distracted into the dark depths of compiling before I have to. However, in Scrivener 3, it seems much more complex – even though the changes are intended to make it simpler. Compile has always been a bit confusing, in that it takes the layout you’ve used to produce the document, then rejigs it for final production and this needs tweaking to get the result you want. And it’s not just me saying this, the forums are full of complaints and confusion. The biggest headache is the redesigned Compile function. It’s also possible to change how it looks if you don’t like the default but, personally, I do. I assume this is due to replicating the Mac. There are new features in Scrivener 3 for Windows, (listed on the Literature and Latté site here) particularly the ability to work with metadata, and the whole layout looks a lot cleaner when you get used to it. I have to say, I’ve never found the in-built Scrivener manual to be enlightening. ![]() There are still, unfortunately, lots of hidden features which need mining of the menu system, and possibly searching through forums and Youtube, to unearth. I’m not sure this will be a problem if someone is coming at it new. A trial version is free to download on the Literature and Latté website.Īs I’ve said, it wasn’t ever a quick program to learn, and the developers have struggled trying to marry what’s possible in Mac with what’s possible in Windows, so users of the earlier version will see a completely different screen layout (see below) and this could be daunting. The birth has been long and arduous, I guess for developers as well as users, but we now have full commercial availability. Mac users have always had the advantage of a wider range of features than in the Windows version, so it was with great excitement when an update, to be called Scrivener 3 for Windows, was announced. I’ve written six novels using Scrivener and my biggest regret is I didn’t have it as a tool when I was writing reports and non-fiction guides – it would have been invaluable. The writing target options help keep track of progress on a document by document and on a project basis (Scrivener 3 even allows targets on a session basis, to keep you at the task).īecause of all this, it’s never been a quick system to learn, though there are lots of videos and massive assistance on the web, but, in my opinion, it’s worth sticking with for the benefits to writing. Whether you are writing novels, short stories or non-fiction, it enables detailed planning and has a really good system of structuring folders, text, research and notes. Readers of these posts will be aware I’m a great fan of Scrivener as a writing tool. Select the deleted WhatsApp Messages that you wish to recover after scanning. Choose WhatsApp Messager and tap on the Start button to begin the process of scanning your device for WhatsApp messages. Connect your device to the computer and select Recover WhatsApp Data from Device Storage. We will take the steps to recover deleted WhatsApp messages on your iPhone as example. Users can preview the messages available before recovering them. It is simple and has a user-friendly interface. It can recover WhatsApp messages without backup. It is most popular among users because of its ease and speed. IMyFone ChatsBack WhatsApp Recvoery has the best features for recovering lost WhatsApp messages on your iPhone and Android. 1 Best WhatsApp Message Recovery App -iMyFone ChatsBack Top 3 WhatsApp Message Recovery Software Top 3 Best WhatsApp Deleted Message Recovery App For instance, they can recover your WhatsApp messages even when you did not back them up. Most of these apps do more than what JewellLoggins commented. That is why this article offers insight into the best WhatsApp message recovery apps. WhatsApp message recovery apps are the most in-demand of the available recovery apps because of the high usage of WhatsApp. ![]() ![]() In these situations, having a recovery app can help to get back lost information. A deleted chat can be very vital in completing a deal or winning a court case. Message recovery apps are now more powerful and essential. If you want to prevent the same thing from happening again, back up the iCloud from your iPhone in advance, and then you can recover deleted text messages, Skype messages, WhatsApp chats with iKeyMonitor." In 2018, a Reddit user asked that, "Is there any software that can recover deleted chats on iPhone?" Then a user with the username of JewellLoggins replied that ''If the logs have already been deleted before you use any recovery software, it may seem impossible to recover. This means that you can take advantage of any tribe bonuses while taking your current Tavern into account. Every turn, after seeing the minions available to you in the Tavern, you get to choose your Hero Power for the turn from two random Hero Powers. Master Nguyen is a unique Hero that is played differently in every game. Together with Kalecgos and Brann, you can generate huge buffs for your board. Peckish Feldrake gains attack from the Hero Power, and so does Stormbringer. If you play Shudderwock with Murlocs, you can keep a Primalfin Lookout on the board and proc the Battlecry with your Hero Power, twice if you also have Young Murk-Eye.ĭragons with Peckish Feldrake and Stormbringer also have great synergy with the Hero. The best tribe for Shudderwock is Murlocs with Brann Bronzebeard. Try to find minions with good Battlecry effects, buffs are especially useful, and keep going with them. This means that you generally want to use it every turn. Shudderwock’s Hero Power costs 0 and triggers a friendly minion’s Battlecry. Reaching 25 Attack during combat also counts, so in-combat buffs can help you get there! Shudderwock Your main goal is to activate your Hero Power. This synergy is so strong that you want to force Naga when playing as Azshara. Until then, Queen Azshara’s Hero Power does nothing, but after that, it turns into Naga Conquest: a one-Gold Hero Power that Discovers a Naga minion up to your current Tavern Tier. ![]() Queen Azshara’s Hero Power becomes active when your warband reaches 25 Attack. Tier six is especially strong, as you can generate Eternal Summoners with additional effects.Īs Professor Putricide, you generally always play with Undead. At least the last Discover should be spent on tier six. Generally, you want to use the Hero Power on tier three for the first time. The minions you Discover are from your Tavern tier or lower. Some of the Undead are from the general Battlegrounds minion pool, and some are specific to Putricide, generally from Constructed Hearthstone. Professor Putricide’s Hero Power allows you to Discover two Undead minions and merge them together. You can generally aim to win the lobby with them and should find yourself in the top 4 most of the time. Click on each one of them to learn more – including how they look like, what their Hero Power is, and why they are put into a given tier / what kind of strategy they usually run. We’ve categorized Heroes into four tiers. That said, this tier list guide can help you choose your Hero based on how useful various Hero Powers are in general. ![]() If you’re having fun with a specific Hero, don’t worry about its tier. Nonetheless, it is possible to win games even on leaderboard ranks with any Hero. Some Heroes are stronger than others, even significantly so. The Battlegrounds Season Pass is currently available only for real money through Runestones. The number of Heroes you can choose from goes up to four if you purchase the Battlegrounds Season Pass that unlocks additional Hero picks and cosmetics. No two players will ever share the same Hero – no one will be offered duplicates. When you start a match, you get two Hero choices and pick one. However, sometimes the right strategy is to ignore your Hero Power altogether and go with strong minions that are offered to you: use your Hero Power to your advantage when you can, but also be ready to choose a different route when you are not offered minions that have synergy with your Hero Power. Some of the Heroes are stronger in the early game, whereas some have good late-game scaling, so you can adapt your strategy to the Hero you’ve picked. While they do not affect the minions offered in the Tavern, each Hero comes with a different Hero Power – a special ability that is either completely passive or an active ability that you can use in the Tavern (between combat phases). Players currently have access to 96 Heroes: the pool changes from time to time with some Heroes being changed, new Heroes being added, and some of the old ones being removed in balance patches. See a full list of minions in our Battlegrounds card database! It doesn’t play like most “Auto Chess” games, and it still feels a lot like Hearthstone, but that might be an advantage! The general idea behind it was to take the popular Auto Battler genre and translate it into Hearthstone. You could even say that it’s a new game built into Hearthstone. Battlegrounds is a different game mode in Hearthstone that completely changes the way you play the game. Still, for cases like the one above, it needed some extra work.Īlso, CleanShot at that time seemed like an excellent macOS app to have for a $15 one-time fee.ĬleanShot is one of those apps that fit so seamlessly into my workflow that I forgot about it down the road. I remember the native screenshot utility on macOS was already decent enough to grab screenshots and videos. One of the main motivations behind getting a copy of the CleanShot app about a year back was to quickly record a part of my screen and turn it into a GIF. It’s the successor to the hugely popular CleanShot app. In this article, I’ll take you through my CleanShot X workflow and tell you how I grab pro-level screenshots with negligible effort. That’s why, to make screenshotting and sharing easy, I use a fantastic app called CleanShot X. Although, macOS’s native screenshot tool is decent for most cases, it’s still a very basic one. Warren, thank you for bringing this up! We are working on a solution and will let you know as soon as we've made the fix! We want to deliver you the best service possible and we are always glad when you take the time and leave a feedback! You can always reach us at when you encounter issues like this.I grab screenshots pretty often. I cringe every time I have to send a drop from my phone…ĭear C. And not once! But twice… After you enter your credentials, the screen flips and it asks you for your credentials again… Really bad. First, you have to login every time you open the app. Drag a file to the little water droplet in your menu bar, boom, you are done. When it comes to sharing files with ease, nothing comes close. Upgrading one star for the response from developers! Really looking forward to the next iteration. I’m a longtime Droplr user and I can’t imagine why for such a great service with such a broad customer base, they can’t produce an app that ENHANCES the utility of the service rather than DETRACTS from it… Dropping the star I added, plus one more because that’s the value I get from the app. UPDATE: Despite the response from the developers, the app still requires double log in. ![]() ![]() It is customers like you that keep us motivated to do better! Thanks for taking the time to share your experience, we appreciate it. Wow! Talk about a power user □ Happy to hear Droplr is adding value to your day to day business. ![]() Whoever did this got my respect! Thanks for bringing back a tool as we designers need for our workflow! I wish you luck to gain back your reputation after all this mess. They basically kill their own app until now! The app works great, and it’s back to business! I’m trying not to cry here. I can send zip files, pictures, files, docs, projects, audio files, everything just with droplr and suddenly they didn’t let you share anything anymore! Just pics or screen videos. The frustration start growing, I try to use Cloudapp, then Cleanshot X, but none of them offer a all-in-one tool like Droplr. Then I managed to get back the legacy app for a while, but I seriously didn’t knew why they changed the app and what kind of users they were after. Then Mobile apps changed and it really start costing me more money trying to keep up with my clients than taking advantage with the new droplr apps! I was forced to use the website to do what I was used with the original apps. It was the tool that make Dropbox obsolete in my workflow. I don’t know who is behind the boss desk now but thanks God the usefulness of this app and service is back !!! I use Droplr as my main tool for sharing docs to my clients. ![]() ![]() At the time of writing the novel (c.1959), Fleming believed that the Cold War might end during the two years it would take to produce a film adaptation, which would leave it looking dated he, therefore, thought it better to create a politically neutral enemy for Bond. The remaining three members are Blofeld himself as leader, a physicist and an electronics expert, added for their expertise on specialist matters. Their top-level members were 21 individuals, 18 of whom handled day-to-day affairs and were drawn in groups of three from six of the world's greatest criminal organisations-the Gestapo, SMERSH, Marshal Josip Broz Tito's secret police, the Mafia, the Unione Corse, and a massive heroin-smuggling operation based in Turkey, as well as a now-defunct intelligence network run by Blofeld. In Ian Fleming's novels, SPECTRE was primarily a commercial enterprise led by Ernst Stavro Blofeld. Originally conceived of as a small group of professional criminals in the novels, SPECTRE became a vast international organisation with its own elaborate facilities and operations in the film series.Ĭomparison of Fiona Volpe's octopus insignia ring from Thunderball (1965), with Marco Sciarra's one from Spectre (2015). SPECTRE is not aligned to any nation or political ideology, enabling the later Bond books and Bond films to be regarded as apolitical. When introduced in 1961, the organisation effectively replaced SMERSH as Bond's primary antagonist. After a four-decade absence from the film series made by EON Productions, the organisation was reintroduced in the twenty-fourth Bond film, Spectre (2015) and reappeared in the twenty-fifth, No Time to Die (2021). Led by 007's nemesis Ernst Stavro Blofeld, the organisation first formally appeared in the novel Thunderball (1961) and subsequently in the movie Dr. SPECTRE (an acronym of Special Executive for Counter-intelligence, Terrorism, Revenge, and Extortion), stylised simply as Spectre in its 2015 film reboot, was a fictional global criminal and terrorist organisation featured in the James Bond novels by Ian Fleming and their EON Productions and non-EON film Never Say Never Again. " SPECTRE is a dedicated fraternity whose strength lies in the absolute integrity of its members." ― Ernst Stavro Blofeld
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